Autophagy restricts HIV-1 infection

Autophagy restricts HIV-1 infection

Human Immunodeficiency Virus type 1 (HIV-1) is a retrovirus that targets cells from the immune system such as the CD4 T lymphocytes, the macrophages and the dendritic cells (DCs). Although these host cells possess various defense mechanisms to fight this infection, HIV-1 has evolved multiple strategies to counteract them. For the past ten years, researchers have been focused on the identificati...

The innate immune factor apolipoprotein L1 restricts HIV-1 infection.

Apolipoprotein L1 (APOL1) is a major component of the human innate immune response against African trypanosomes. Although the mechanism of the trypanolytic activity of circulating APOL1 has been recently clarified, the intracellular function(s) of APOL1 in human cells remains poorly defined. Like that of many genes linked to host immunity, APOL1 expression is induced by proinflammatory cytokine...

The innate immune factor apolipoprotein L 1 ( APOL 1 ) restricts HIV - 1 infection

Roles of autophagy in HIV infection.

Autophagy is a major cellular pathway, which at basal levels regulates and maintains the cytoplasmic environment through the capture, isolation and digestion of intracellular materials in a specialized structure called an autophagosome. The unique ability of autophagy to degrade large targets, such as damaged and surplus organelles, intracellular microbes and protein aggregates, has made it a p...

Evaluation of clinical course and laboratory findings in HIV/HTLV-1 co-infection compare with HIV mono infection

Background: In the last 10 years, co-infection of human immunodeficiency virus/human T-cell leukemia virus-1 (HIV/HTLV-1) has emerged as a worldwide health problem. These viruses has the same route to infect human but different effects on CD4 positive T-cells. There was controversial results about the influence of co-infection HIV/HTLV-1 pathogenesis. This study compared clinical course and lab...